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IVISense Pan Cathepsin 750 FAST Fluorescent Probe (ProSense)

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SKU NEV11171

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Proteases perform a fundamental role in protein regulation. Altered activity of lysosomal cathepsins, a class of protease, can indicate many disease-related processes, such as those involved in cancer, inflammation, arthritis, cardiovascular and many others. The ability to detect and quantify normal as well as altered protease cathepsin activity in vivo allows the progress and severity of these disease states to be tracked and interrogated over time.

Revvity’s IVISense™ Pan Cathepsin fluorescent probes (ProSense®) are versatile pan-cathepsin-activatable NIR agents for imaging various disease-related events. These activatable probes are optically silent in their intact state and become highly fluorescent following protease-mediated cleavage and activation.

IVISense Pan Cathepsin 750 FAST is a member of a family of activatable fluorescent imaging agents comprising a novel architecture, termed F.A.S.T. (Fluorescent Activatable Sensor Technology) that confers an improved pharmacokinetic profile with a broader range of early imaging time points. This architecture also offers higher target specific signal with reduced background. IVISense Pan Cathepsin 750 FAST offers faster activation after injection; it can be imaged at earlier times for optimized work flow, or for applications such as acute inflammation models. 4-24h imaging at 750 nm.

For laboratory use only. This product is intended for animal research only and not for use in humans.

Spetsifikatsioon

Spetsifikatsioon
Product Brand Name

ProSense

Therapeutic Area

Atherosclerosis, Arthritis, Inflammation, Oncology/Cancer

Wavelength

750 nm

Unit Size

1 Vial (10 doses)

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Ettevõttest

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Kaštonų g. 56, Giraitės k, LT-54310,
Kaunas, Lithuania

nova@novabio.lt
Phone: +370 (620) 70159

Reg No 305063819

Nova Natura OÜ

Valukoja 8, 11415,
Tallinn, Estonia

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Phone: +37251939223

Reg No 14758203

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