Matrix metalloproteinases (MMPs) are calcium-dependent zinc containing endopeptidases responsible for the degradation of most of extracellular matrix proteins during organogenesis, growth and normal tissue turnover. MMPs play a role in almost every biological cell process from embryo implantation to cell death and have been implicated in a wide range of diseases including inflammation, arthritis, pulmonary disease, cancer and more.
Revvity’s IVISense™ MMP NIR activatable fluorescence probes (MMPSense®) are designed to evaluate many disease related processes including cancer progression, rheumatoid arthritis, pulmonary disease and more as well as evaluating therapeutic efficacy of potential drug candidates.
IVISense MMP 750 FAST is excited by 749 nm excitation light, and emits at 775 nm. MMP 750 FAST is a member of a family of activatable fluorescent imaging agents comprising a novel architecture termed F.A.S.T. (Fluorescent Activatable Sensor Technology), that allows for an earlier optimal imaging window of 12-24 hours after injection, facilitating detection of MMP activity changes in acute models of inflammation or stroke. In addition, the 750 nm wavelength is optimal for minimizing the impact of autofluorescence and chow-related fluorescence that can interfere with image quality. Including IVISense MMP 750 FAST in careful experimental design allows for multiplexing with other channels and/or imaging times, and so can be paired with other probes to achieve maximum efficiency and flexibility in imaging.
For laboratory use only. This product is intended for animal research only and not for use in humans.
