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Tasuta koolitus - "Assay Guidance Workshop for Cell-Based Assays and Lead Discovery" (16-17. Nov 2021, virtuaalne)

Assay Guidance Workshop for Cell-Based Assays and Lead Discovery

Tuesday November 16, 2021 – Wednesday November 17, 2021 Virtual (All times are in EEST)



AGENDA: Day 1: High-Content Screening and Analysis

19:30 PM NCATS Assay Guidance Manual: Setting the Standard for Rigor in Translational Science

Sarine Markossian, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH)

19:45 PM The Evolution of HCS Imaging and Impact on Discovery

Joe Trask, PerkinElmer

20:15 PM Assay Development for Imaging Assays: Design, Data Management and Validation

Steven Haney, Valo Health

20:45 PM Introduction to High Content Image Analysis with CellProfiler

Beth Cimini, Broad Institute

21:15 PM Break

21:30 PM Machine Learning and Assay Development

Jonathan Sexton, University of Michigan, Ann Arbor

22:00 PM Transforming Drug Discovery via Image-Based Profiling

Niranj Chandrasekaran, Broad Institute

22:30 PM Break

22:45 PM Functional Genomics: Taking Discovery to the Third Dimension

Kaylene Simpson, Peter MacCallum Cancer Centre

23:15 PM Panel Discussion – Challenges and Applications of HCS

Moderator: Kaylene Simpson, Peter MacCallum Cancer Centre

Panelists: Joe Trask, PerkinElmer; Steven Haney, Valo Health; Beth Cimini, Broad Institute; Jonathan Sexton, University of Michigan, Ann Arbor; David Egan, Core Life Analytics; Niranj Chandrasekaran, Broad Institute

00:00 PM Adjourn

AGENDA: Day 2: Complex In vitro Models (CIVMs) in Drug Discovery

20:00 PM Opening Note

Sarine Markossian, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH)

20:05 PM Drug Screening with Engineered 3D Tissue Models

Marc Ferrer, NCATS, NIH

20:35 PM Organ-Chips: From Potential to Application

Lorna Ewart, Emulate

21:05 PM TBD

Jan Lichtenberg, InSphero AG

21:35 PM Break

21:45 PM Developing Scalable Complex Models for High Throughput Screening

BanuPriya Sridharan, GlaxoSmithKline

22:15 PM Validating Cell Health Assays Applied to 3D Cultures

Terry Riss, Promega Corporation

22:45 PM Break

23:00 PM Applying a Holistic Approach for 3D HCS Imaging Assays

Joe Trask, PerkinElmer

23:30 PM Panel Discussion – Challenges and Applications of CIVMs in Drug Discovery

Moderator: Madhu Lal-Nag, FDA

Panelists: Marc Ferrer, NCATS; Lorna Ewart, Emulate; Jan Lichtenberg, InSphero AG; BanuPriya Sridharan, GlaxoSmithKline; Terry Riss, Promega Corporation; Joe Trask, PerkinElmer

00:15 AM Adjourn



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